Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway

Group IVA cytosolic phospholipase A(2) (cPLA(2)α), which preferentially cleaves arachidonic acid from phospholipids, plays a role in apoptosis and tissue injury. Downstream signals in response to tumor necrosis factor (TNF)-α, a mediator of myocardial ischemia-reperfusion (I/R) injury, involve cPLA(...

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Bibliografiske detaljer
Main Authors: Saito, Yukio, Watanabe, Kazuhiro, Fujioka, Daisuke, Nakamura, Takamitsu, Obata, Jun-ei, Kawabata, Kenichi, Watanabe, Yosuke, Mishina, Hideto, Tamaru, Shun, Kita, Yoshihiro, Shimizu, Takao, Kugiyama, Kiyotaka
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
Fag:
Integrative Cardiovascular Physiology and Pathophysiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362116/
https://ncbi.nlm.nih.gov/pubmed/22427514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00955.2011
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