A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly

AnkyrinG (ankG) is highly enriched in neurons at axon initial segments (AIS) where it clusters Na+ and K+ channels and maintains neuronal polarity. How ankG becomes concentrated at the AIS is unknown. Here, we show that as neurons break symmetry, they assemble a distal axonal submembranous cytoskele...

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Auteurs principaux: Galiano, Mauricio R., Jha, Smita, Ho, Tammy SzuYu, Zhang, Chuansheng, Ogawa, Yasuhiro, Chang, Kae-Jiun, Stankewich, Michael C., Mohler, Peter J., Rasband, Matthew N.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361702/
https://ncbi.nlm.nih.gov/pubmed/22632975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.039
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