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ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination
OBJECTIVE: Dietary ω-6 lipids such as linoleic acid and its oxidized forms (13-HPODE-OxLA) interact with peroxisome proliferator-activated receptors (PPARs) and elicit pro-and anti-atherogenic effects in vascular cells. Ligand-dependent PPAR protein turnover is promoted by ubiquitination, but attenu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361620/ https://ncbi.nlm.nih.gov/pubmed/22464285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2012.02.040 |
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