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Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice.

The peptide-Z-Pro-D-Leu, injected daily in mice receiving morphine chronically, was found to prevent development of physical dependence as measured by changes in body temperature and body weight due either to abrupt or to naloxone-induced withdrawal. On the other hand, administration of Z-Pro-D-Leu...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Walter, R, Ritzmann, R F, Bhargava, H N, Rainbow, T C, Flexner, L B, Krivoy, W A
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1978
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC336159/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/279936/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.9.4573
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