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Prolyl-leucyl-glycinamide, cyclo(leucylglycine), and derivatives block development of physical dependence on morphine in mice.

Pro-Leu-Gly-NH2 (MIF) and several structural analogues, all injected in 50-microgram doses daily in mice receiving morphine chronically, were found to prevent development of physical dependence as measured by changes in body temperature associated with naloxone-induced withdrawal. Dose-response stud...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Walter, R, Ritzmann, R F, Bhargava, H N, Flexner, L B
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 1979
Aiheet:
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC382973/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/284370/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.1.518
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