Disruption of the ECM33 Gene in Candida albicans Prevents Biofilm Formation, Engineered Human Oral Mucosa Tissue Damage and Gingival Cell Necrosis/Apoptosis

In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues. This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains...

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Bibliographic Details
Main Authors: Rouabhia, Mahmoud, Semlali, Abdelhabib, Chandra, Jyotsna, Mukherjee, Pranab, Chmielewski, Witold, Ghannoum, Mahmoud A.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361342/
https://ncbi.nlm.nih.gov/pubmed/22665950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/398207
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