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Molecular Dynamics Simulations of Voltage-Gated Cation Channels: Insights on Voltage-Sensor Domain Function and Modulation

Since their discovery in the 1950s, the structure and function of voltage-gated cation channels (VGCC) has been largely understood thanks to results stemming from electrophysiology, pharmacology, spectroscopy, and structural biology. Over the past decade, computational methods such as molecular dyna...

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Main Authors: Delemotte, Lucie, Klein, Michael L., Tarek, Mounir
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Research Foundation 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361024/
https://ncbi.nlm.nih.gov/pubmed/22654756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00097
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