Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-2 spectrin

We use 1,2-diacetylbenzene (1,2-DAB) to probe molecular mechanisms of proximal giant neurofilamentous axonopathy (PGNA), a pathological hallmark of amyotrophic lateral sclerosis. The spinal cord proteome of rodents displaying 1,2-DAB-PGNA suggests a reduction in the abundance of αII-spectrin (Spna2)...

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Main Authors: Kassa, R., Monterroso, V., Wentzell, J., Ramos, A.L., Couchi, E., Lecomte, MC, Iordanov, M, Kretzschmar, D., Nicolas, G., Tshala-Katumbay, D.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360998/
https://ncbi.nlm.nih.gov/pubmed/22212489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-011-9699-8
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