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Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-2 spectrin
We use 1,2-diacetylbenzene (1,2-DAB) to probe molecular mechanisms of proximal giant neurofilamentous axonopathy (PGNA), a pathological hallmark of amyotrophic lateral sclerosis. The spinal cord proteome of rodents displaying 1,2-DAB-PGNA suggests a reduction in the abundance of αII-spectrin (Spna2)...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3360998/ https://ncbi.nlm.nih.gov/pubmed/22212489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-011-9699-8 |
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