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Potent and Selective Peptidyl Boronic Acid Inhibitors of the Serine Protease Prostate-Specific Antigen

Prostate cancer cells produce high (microgram to milligram/milliliter) levels of the serine protease Prostate-Specific Antigen (PSA). PSA is enzymatically active in the extracellular fluid surrounding prostate cancers but is found at 1,000- to 10,000-fold lower concentrations in the circulation, whe...

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Autors principals: LeBeau, Aaron M., Singh, Pratap, Isaacs, John T., Denmeade, Samuel R.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360951/
https://ncbi.nlm.nih.gov/pubmed/18635003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.05.020
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