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Tamoxifen and CYP2D6: A Contradiction of Data
Tamoxifen is an effective antiestrogen used in the treatment of hormone receptor–positive breast cancer. Bioconversion of tamoxifen to endoxifen, its most abundant active metabolite, is primarily dependent on the activity of cytochrome P450 2D6 (CYP2D6), which is highly polymorphic. Over 20 publishe...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
AlphaMed Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3360902/ https://ncbi.nlm.nih.gov/pubmed/22531359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2011-0418 |
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