Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a prototypical autoimmune arthritis affecting nearly 1% of the world population and is a significant cause of worldwide disability. Though prior studies have demonstrated the appearance of RA-related autoantibodies years before the onset of clinical RA, the pattern of im...

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Main Authors: Sokolove, Jeremy, Bromberg, Reuven, Deane, Kevin D., Lahey, Lauren J., Derber, Lezlie A., Chandra, Piyanka E., Edison, Jess D., Gilliland, William R., Tibshirani, Robert J., Norris, Jill M., Holers, V. Michael, Robinson, William H.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360701/
https://ncbi.nlm.nih.gov/pubmed/22662108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035296
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