Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis.

Rheumatoid arthritis (RA) is a prototypical autoimmune arthritis affecting nearly 1% of the world population and is a significant cause of worldwide disability. Though prior studies have demonstrated the appearance of RA-related autoantibodies years before the onset of clinical RA, the pattern of im...

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Main Authors: Jeremy Sokolove, Reuven Bromberg, Kevin D Deane, Lauren J Lahey, Lezlie A Derber, Piyanka E Chandra, Jess D Edison, William R Gilliland, Robert J Tibshirani, Jill M Norris, V Michael Holers, William H Robinson
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3360701?pdf=render
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