Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

The fate of the guanyl nucleotide bound to the regulatory site of adenylate cyclase was studied on a preparation of turkey erythrocyte membranes that was incubated with [3H]GTP plus isoproterenol and subsequently washed to remove hormone and free guanyl nucleotide. Further incubation of this prepara...

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Bibliographic Details
Main Authors: Cassel, D, Selinger, Z
Format: Artigo
Language:Inglês
Published: 1978
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC336070/
https://ncbi.nlm.nih.gov/pubmed/212737
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