The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer

PURPOSE: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian cancer risk in patients from hereditary breast and ovarian families (HBOC), a...

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Autori principali: Pilarski, Robert, Patel, Divya A., Weitzel, Jeffrey, McVeigh, Terri, Dorairaj, Jemima J., Heneghan, Helen M., Miller, Nicola, Weidhaas, Joanne B., Kerin, Michael J., McKenna, Megan, Wu, Xifeng, Hildebrandt, Michelle, Zelterman, Daniel, Sand, Sharon, Shulman, Lee P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360659/
https://ncbi.nlm.nih.gov/pubmed/22662244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037891
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