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Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine.

The damage to DNA by the hepatocarcinogen aflatoxin B1 was investigated. A DNA fragment of known sequence of the lactose promoter-operator region was used as a substrate for modification by aflatoxin B1. The DNA was incubated with aflatoxin B1 in crude mammalian liver extracts or with purified micro...

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Bibliografske podrobnosti
Main Authors: D'Andrea, A D, Haseltine, W A
Format: Artigo
Jezik:Inglês
Izdano: 1978
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC336063/
https://ncbi.nlm.nih.gov/pubmed/30083
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