Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine.
The damage to DNA by the hepatocarcinogen aflatoxin B1 was investigated. A DNA fragment of known sequence of the lactose promoter-operator region was used as a substrate for modification by aflatoxin B1. The DNA was incubated with aflatoxin B1 in crude mammalian liver extracts or with purified micro...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1978
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC336063/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/30083/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.9.4120 |
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