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Bmp2, Bmp4 and Bmp7 Are Co-Required in the Mouse AER for Normal Digit Patterning but Not Limb Outgrowth

Outgrowth and patterning of the vertebrate limb requires a functional apical ectodermal ridge (AER). The AER is a thickening of ectodermal tissue located at the distal end of the limb bud. Loss of this structure, either through genetic or physical manipulations results in truncation of the limb. A n...

詳細記述

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書誌詳細
主要な著者: Choi, Kyung-Suk, Lee, Chanmi, Maatouk, Danielle M., Harfe, Brian D.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360612/
https://ncbi.nlm.nih.gov/pubmed/22662233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037826
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