p53 Modulation as a Therapeutic Strategy in Gastrointestinal Stromal Tumors

The KIT-inhibitor imatinib mesylate (IM) has greatly improved the treatment of metastatic gastrointestinal stromal tumors (GIST). IM exhibits strong antiproliferative effects but fails to induce sufficient levels of apoptosis resulting in low pathologic complete remission rates and a high rate of se...

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Detalhes bibliográficos
Main Authors: Henze, Joern, Mühlenberg, Thomas, Simon, Susanne, Grabellus, Florian, Rubin, Brian, Taeger, Georg, Schuler, Martin, Treckmann, Juergen, Debiec-Rychter, Maria, Taguchi, Takahiro, Fletcher, Jonathan A., Bauer, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360609/
https://ncbi.nlm.nih.gov/pubmed/22662219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037776
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