Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload

Thrombospondin-4 (TSP-4) expression increases dramatically in hypertrophic and failing hearts in rodent models and in humans. The aim of this study was to address the function of TSP-4 in the heart. TSP-4-knockout (Thbs4(−/−)) and wild-type (WT) mice were subjected to transverse aortic constriction...

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Detalhes bibliográficos
Main Authors: Frolova, Ella G., Sopko, Nikolai, Blech, Lauren, Popović, Zoran B., Li, Jianbo, Vasanji, Amit, Drumm, Carla, Krukovets, Irene, Jain, Mukesh K., Penn, Marc S., Plow, Edward F., Stenina, Olga I.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360147/
https://ncbi.nlm.nih.gov/pubmed/22362893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-190728
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