Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage

CCDC6 was originally identified in chimeric genes caused by chromosomal translocation involving the RET proto-oncogene in some thryoid tumors mostly upon ionizing radiation exposure. Recognised as a pro-apoptotic phosphoprotein that negatively regulates CREB1-dependent transcription, CCDC6 is an ATM...

Full description

Saved in:
Bibliographic Details
Main Authors: Merolla, Francesco, Luise, Chiara, Muller, Mark T., Pacelli, Roberto, Fusco, Alfredo, Celetti, Angela
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360053/
https://ncbi.nlm.nih.gov/pubmed/22655027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036177
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items