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Identification of Sumoylation Sites in CCDC6, the First Identified RET Partner Gene in Papillary Thyroid Carcinoma, Uncovers a Mode of Regulating CCDC6 Function on CREB1 Transcriptional Activity

CCDC6 was originally identified in chimeric genes as caused by chromosomal translocation involving the RET protooncogene in some thyroid tumors. Recognised as a 65 kDa pro-apoptotic phosphoprotein, CCDC6 has been enrolled as an ATM substrate that contribute to protect genome integrity by modulating...

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Bibliografski detalji
Glavni autori: Luise, Chiara, Merolla, Francesco, Leone, Vincenza, Paladino, Simona, Sarnataro, Daniela, Fusco, Alfredo, Celetti, Angela
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492267/
https://ncbi.nlm.nih.gov/pubmed/23145146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049298
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