Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases

Rationale: Tuberculosis kills more than 1.5 million people per year, and standard treatment has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix metalloproteinase (MMP) activity to cause immunopathology. In advanced HIV infection, tissue destruction is reduced, but underlyi...

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Detalhes bibliográficos
Main Authors: Walker, Naomi F., Clark, Simon O., Oni, Tolu, Andreu, Nuria, Tezera, Liku, Singh, Shivani, Saraiva, Luísa, Pedersen, Bernadette, Kelly, Dominic L., Tree, Julia A., D'Armiento, Jeanine M., Meintjes, Graeme, Mauri, Francesco A., Williams, Ann, Wilkinson, Robert J., Friedland, Jon S., Elkington, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359940/
https://ncbi.nlm.nih.gov/pubmed/22345579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201110-1769OC
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