Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases

Rationale: Tuberculosis kills more than 1.5 million people per year, and standard treatment has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix metalloproteinase (MMP) activity to cause immunopathology. In advanced HIV infection, tissue destruction is reduced, but underlyi...

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Autors principals: Walker, Naomi F., Clark, Simon O., Oni, Tolu, Andreu, Nuria, Tezera, Liku, Singh, Shivani, Saraiva, Luísa, Pedersen, Bernadette, Kelly, Dominic L., Tree, Julia A., D'Armiento, Jeanine M., Meintjes, Graeme, Mauri, Francesco A., Williams, Ann, Wilkinson, Robert J., Friedland, Jon S., Elkington, Paul T.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359940/
https://ncbi.nlm.nih.gov/pubmed/22345579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201110-1769OC
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