Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases

Rationale: Tuberculosis kills more than 1.5 million people per year, and standard treatment has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix metalloproteinase (MMP) activity to cause immunopathology. In advanced HIV infection, tissue destruction is reduced, but underlyi...

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Main Authors: Walker, Naomi F., Clark, Simon O., Oni, Tolu, Andreu, Nuria, Tezera, Liku, Singh, Shivani, Saraiva, Luísa, Pedersen, Bernadette, Kelly, Dominic L., Tree, Julia A., D'Armiento, Jeanine M., Meintjes, Graeme, Mauri, Francesco A., Williams, Ann, Wilkinson, Robert J., Friedland, Jon S., Elkington, Paul T.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Thoracic Society 2012
נושאים:
Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359940/
https://ncbi.nlm.nih.gov/pubmed/22345579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201110-1769OC
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