5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals

Epoxyeicosatrienoic acids (EETs) are cytochrome P450-epoxygenase-derived metabolites of arachidonic acid that act as endogenous signaling molecules in multiple biological systems. Here we have investigated the specific contribution of 5,6-EET to transient receptor potential (TRP) channel activation...

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Main Authors: Sisignano, Marco, Park, Chul-Kyu, Angioni, Carlo, Zhang, Dong Dong, von Hehn, Christian, Cobos, Enrique J., Ghasemlou, Nader, Xu, Zhen-Zhong, Kumaran, Vigneswara, Lu, Ruirui, Grant, Andrew, Fischer, Michael J. M., Schmidtko, Achim, Reeh, Peter, Ji, Ru-Rong, Woolf, Clifford J., Geisslinger, Gerd, Scholich, Klaus, Brenneis, Christian
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359875/
https://ncbi.nlm.nih.gov/pubmed/22553041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5793-11.2012
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