GATA4 Is a Critical Regulator of Gonadectomy-Induced Adrenocortical Tumorigenesis in Mice

In response to gonadectomy certain inbred mouse strains develop sex steroidogenic adrenocortical neoplasms. One of the hallmarks of neoplastic transformation is expression of GATA4, a transcription factor normally present in gonadal but not adrenal steroidogenic cells of the adult mouse. To show tha...

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Dettagli Bibliografici
Autori principali: Krachulec, Justyna, Vetter, Melanie, Schrade, Anja, Löbs, Ann-Kathrin, Bielinska, Malgorzata, Cochran, Rebecca, Kyrönlahti, Antti, Pihlajoki, Marjut, Parviainen, Helka, Jay, Patrick Y., Heikinheimo, Markku, Wilson, David B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2012
Soggetti:
Cancer-Oncogenes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359595/
https://ncbi.nlm.nih.gov/pubmed/22461617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-2135
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