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Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis

Hepatoblastoma, the most common type of pediatric liver cancer, is treated with a combination of surgery and chemotherapy. An essential drug in the treatment of hepatoblastoma is doxorubicin, which in high doses is cardiotoxic. This adverse effect is due to downregulation of cardiac expression of tr...

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Autors principals: Tea Soini, Marjut Pihlajoki, Antti Kyrönlahti, Leif C Andersson, David B Wilson, Markku Heikinheimo
Format: Artigo
Idioma:Inglês
Publicat: SAGE Publishing 2017-03-01
Col·lecció:Tumor Biology
Accés en línia:https://doi.org/10.1177/1010428317695016
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