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COMT Val(158)Met genotype influences neurodegeneration within dopamine-innervated brain structures

OBJECTIVE: We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions. METHODS: A total of 252 subjects, including healthy controls and patients with Alzheimer disease, behavioral v...

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Detalhes bibliográficos
Main Authors: Gennatas, E.D., Cholfin, J.A., Zhou, J., Crawford, R.K., Sasaki, D.A., Karydas, A., Boxer, A.L., Bonasera, S.J., Rankin, K.P., Gorno-Tempini, M.L., Rosen, H.J., Kramer, J.H., Weiner, M., Miller, B.L., Seeley, W.W.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359506/
https://ncbi.nlm.nih.gov/pubmed/22573634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3182574fa1
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