Kinetic studies of novel inhibitors of endomorphin degrading enzymes

Endomorphins (EMs), two endogenous μ-opioid receptor selective ligands, are attractive lead compounds for opioid-based pain management studies. However, these peptides are quickly degraded by peptidases, in particular by dipeptidylpeptidase IV (DPP IV) and aminopeptidase M (APM). Targeting enzymatic...

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Bibliografske podrobnosti
Main Authors: Perlikowska, Renata, Fichna, Jakub, do-Rego, Jean Claude, Gach, Katarzyna, Janecka, Anna
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2011
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359464/
https://ncbi.nlm.nih.gov/pubmed/22707871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-011-9666-5
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