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Macromolecular Crowding Directs Extracellular Matrix Organization and Mesenchymal Stem Cell Behavior

Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture. Here, we induced macromolecular crowding in vitro by using synthetic macromolecular globules of nm-scale radius at phy...

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Detalhes bibliográficos
Main Authors: Zeiger, Adam S., Loe, Felicia C., Li, Ran, Raghunath, Michael, Van Vliet, Krystyn J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359376/
https://ncbi.nlm.nih.gov/pubmed/22649562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037904
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