Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

Increased expression of several osteoblastic proteases and MEPE (a bone matrix protein) occurs in X-linked hypophosphatemic rickets (hyp). This is associated with an increased release of a protease-resistant MEPE peptide (ASARM peptide), a potent inhibitor of mineralization. Cathepsin B cleaves MEPE...

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Detalhes bibliográficos
Main Authors: Rowe, Peter S.N., Matsumoto, Naoko, Jo, Oak D., Shih, Remi N.J., Oconnor, Jeannine, Roudier, Martine P., Bain, Steve, Liu, Shiguang, Harrison, Jody, Yanagawa, Norimoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358922/
https://ncbi.nlm.nih.gov/pubmed/16762607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2006.04.012
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