Cocaine Self-Administration Produces Pharmacodynamic Tolerance: Differential Effects on the Potency of Dopamine Transporter Blockers, Releasers, and Methylphenidate

The dopamine transporter (DAT) is the primary site of action for psychostimulant drugs such as cocaine, methylphenidate, and amphetamine. Our previous work demonstrated a reduced ability of cocaine to inhibit the DAT following high-dose cocaine self-administration (SA), corresponding to a reduced ab...

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Autors principals: Ferris, Mark J, Calipari, Erin S, Mateo, Yolanda, Melchior, James R, Roberts, David CS, Jones, Sara R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358740/
https://ncbi.nlm.nih.gov/pubmed/22395730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.17
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