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Heat Shock Protein gp96 regulates Toll-Like Receptor 9 proteolytic processing and conformational stability
Nucleic acid-sensing Toll-like receptors (TLRs) initiate innate immune responses to foreign RNA and DNA, yet can detect and respond to host DNA. To avoid autoimmune pathologies, nucleic acid sensing TLRs are tightly regulated. TLR9 primarily resides in the endoplasmic reticulum, traffics to endosome...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358552/ https://ncbi.nlm.nih.gov/pubmed/22554506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.04.083 |
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