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Binding, internalization, and degradation of low density lipoprotein by normal human fibroblasts and by fibroblasts from a case of homozygous familial hypercholesterolemia.

Skin fibroblasts from a patient with homozygous familial hypercholesterolemia (HFH) were compared with normal skin fibroblasts with regard to binding, internalization, and degradation of iodinated human low density lipoprotein (LDL). Like other cell lines from HFH patients, the mutant cells showed n...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Stein, O, Weinstein, D B, Stein, Y, Steinberg, D
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1976
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC335829/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/174096/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.1.14
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