Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells

Aging is enhanced by hypoxia and oxidative stress. As the lens is located in the hypoglycemic environment under hypoxia, aging lens with diabetes might aggravate these stresses. This study was designed to examine whether low glucose under hypoxic conditions induces the unfolded protein response (UPR...

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Detalhes bibliográficos
Main Authors: Elanchezhian, R, Palsamy, P, Madson, C J, Mulhern, M L, Lynch, D W, Troia, A M, Usukura, J, Shinohara, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358018/
https://ncbi.nlm.nih.gov/pubmed/22513875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.40
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