Resistance to ABT-737 in activated T lymphocytes: molecular mechanisms and reversibility by inhibition of the calcineurin–NFAT pathway

Dynamic regulation of the intrinsic apoptosis pathway controls central and peripheral lymphocyte deletion, and may interfere with the pro-apoptotic potency of B-cell lymphoma 2 inhibitors such as ABT-737. By following a T-cell receptor (TCR) transgenic population of alloantigen-specific T cells, we...

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Autors principals: Cippà, P E, Kraus, A K, Lindenmeyer, M T, Chen, J, Guimezanes, A, Bardwell, P D, Wekerle, T, Wüthrich, R P, Fehr, T
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358016/
https://ncbi.nlm.nih.gov/pubmed/22513873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.38
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