Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity

Although targeting of the death receptors (DRs) DR4 and DR5 still appears a suitable antitumoral strategy, the limited clinical responses to recombinant soluble TNF-related apoptosis inducing ligand (TRAIL) necessitate novel reagents with improved apoptotic activity/tumor selectivity. Apoptosis indu...

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Bibliographische Detailangaben
Hauptverfasser: Siegemund, M, Pollak, N, Seifert, O, Wahl, K, Hanak, K, Vogel, A, Nussler, A K, Göttsch, D, Münkel, S, Bantel, H, Kontermann, R E, Pfizenmaier, K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358007/
https://ncbi.nlm.nih.gov/pubmed/22495350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.29
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