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Penicillamine Increases Free Copper and Enhances Oxidative Stress in the Brain of Toxic Milk Mice
Wilson disease (WD) is characterized by the accumulation of copper arising from a mutation in the ATP7B gene. Penicillamine (PA) makes 10–50% of the patients with neurologic symptoms neurologically worse at the early stage of administration. The aim of this study was to determine how the copper meta...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3357430/ https://ncbi.nlm.nih.gov/pubmed/22629446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037709 |
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