Design, synthesis and biological characterization of novel inhibitors of CD38

Human CD38 is a novel multi-functional protein that acts not only as an antigen for B-lymphocyte activation, but also an enzyme catalyzing the synthesis of a Ca(2+) messenger molecule, cyclic ADP-ribose, from NAD(+). It is well established that this novel Ca(2+) signaling enzyme is responsible for r...

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Autors principals: Dong, Min, Si, Yuan-Qi, Sun, Shuang-Yong, Pu, Xiao-Ping, Yang, Zhen-Jun, Zhang, Liang-Ren, Zhang, Li-He, Leung, Fung Ping, Lam, Connie Mo Ching., Kwong, Anna Ka Yee, Yue, Jianbo, Zhou, Yeyun, Kriksunov, Irina A., Hao, Quan, Lee, Hon Cheung
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357394/
https://ncbi.nlm.nih.gov/pubmed/21431168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0ob00768d
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