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Artificially designed promoters: Understanding the role of spatial features and canonical binding sites in transcription

The promoter is a key element in gene transcription and regulation. We previously reported that artificial sequences rich in the dinucleotide CpG are sufficient to drive expression in vitro in mammalian cell lines, without requiring canonical binding sites for transcription factor proteins. Here, we...

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Detalhes bibliográficos
Main Authors: Baumann, Martina, Höppner, Marc P., Meier, Michael, Pontiller, Jens, Ernst, Wolfgang, Grabherr, Reingard, Mauceli, Evan, Grabherr, Manfred G.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357332/
https://ncbi.nlm.nih.gov/pubmed/22095054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bbug.18530
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