Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

Defective liver gluconeogenesis is the main mechanism leading to fasting hyperglycemia in type 2 diabetes, and, in concert with steatosis, it is the hallmark of hepatic insulin resistance. Experimental obesity results, at least in part, from hypothalamic inflammation, which leads to leptin resistanc...

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Hauptverfasser: Milanski, Marciane, Arruda, Ana P., Coope, Andressa, Ignacio-Souza, Letícia M., Nunez, Carla E., Roman, Erika A., Romanatto, Talita, Pascoal, Livia B., Caricilli, Andrea M., Torsoni, Marcio A., Prada, Patricia O., Saad, Mario J., Velloso, Licio A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2012
Schlagworte:
Obesity Studies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357298/
https://ncbi.nlm.nih.gov/pubmed/22522614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0390
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