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Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation

Inconsistent expression and regulation of drug-metabolizing enzymes (DMEs) are common causes of adverse drug effects in some drugs with a narrow therapeutic index (TI). An important cytochrome, cytochrome P450 3A4 (CYP3A4), is predominantly regulated by a nuclear receptor, pregnane X receptor (PXR)....

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書誌詳細
主要な著者: Lim, Yun-Ping, Ma, Chia-Yun, Liu, Cheng-Ling, Lin, Yu-Hsien, Hu, Miao-Lin, Chen, Jih-Jung, Hung, Dong-Zong, Hsieh, Wen-Tsong, Huang, Jin-Ding
フォーマット: Artigo
言語:Inglês
出版事項: Hindawi Publishing Corporation 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356939/
https://ncbi.nlm.nih.gov/pubmed/22645625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/242810
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