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Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation
Inconsistent expression and regulation of drug-metabolizing enzymes (DMEs) are common causes of adverse drug effects in some drugs with a narrow therapeutic index (TI). An important cytochrome, cytochrome P450 3A4 (CYP3A4), is predominantly regulated by a nuclear receptor, pregnane X receptor (PXR)....
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主要な著者: | , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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Hindawi Publishing Corporation
2012
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3356939/ https://ncbi.nlm.nih.gov/pubmed/22645625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/242810 |
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