Unexpected fold in the circumsporozoite protein target of malaria vaccines

Circumsporozoite (CS) protein is the major surface component of Plasmodium falciparum sporozoites and is essential for host cell invasion. A vaccine containing tandem repeats, region III, and thrombospondin type-I repeat (TSR) of CS is efficacious in phase III trials but gives only a 35% reduction i...

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Detalhes bibliográficos
Main Authors: Doud, Michael B., Koksal, Adem C., Mi, Li-Zhi, Song, Gaojie, Lu, Chafen, Springer, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356675/
https://ncbi.nlm.nih.gov/pubmed/22547819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205737109
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