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Unexpected fold in the circumsporozoite protein target of malaria vaccines
Circumsporozoite (CS) protein is the major surface component of Plasmodium falciparum sporozoites and is essential for host cell invasion. A vaccine containing tandem repeats, region III, and thrombospondin type-I repeat (TSR) of CS is efficacious in phase III trials but gives only a 35% reduction i...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3356675/ https://ncbi.nlm.nih.gov/pubmed/22547819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205737109 |
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