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Sunitinib Inhibits Cell Proliferation and Alters Steroidogenesis by Down-Regulation of HSD3B2 in Adrenocortical Carcinoma Cells

The multi-tyrosine kinase inhibitor sunitinib is used in the treatment of several solid tumors. Animal experiments pointed to an adrenotoxic effect of sunitinib. Therefore, we evaluated the expression of key targets of sunitinib in human adrenocortical carcinoma (ACC) tumor samples and investigated...

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Detalhes bibliográficos
Main Authors: Kroiss, Matthias, Reuss, Miriam, Kühner, Dorothee, Johanssen, Sarah, Beyer, Melanie, Zink, Martina, Hartmann, Michaela F., Dhir, Vivek, Wudy, Stefan A., Arlt, Wiebke, Sbiera, Silviu, Allolio, Bruno, Fassnacht, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356136/
https://ncbi.nlm.nih.gov/pubmed/22654799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2011.00027
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