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A minimal fluorous tagging strategy enables the synthesis of the complete stereoisomer library of Sch725674 macrolactones

Four mixtures of four fluorous-tagged quasiisomers have been synthesized, demixed and detagged to make all 16 stereoisomers of the macrocyclic lactone natural product Sch725674. A new bare-minimum tagging pattern needs only two tags— one fluorous and one non-fluorous—to encode four isomers. The stru...

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Dettagli Bibliografici
Autori principali: Moretti, Jared D., Wang, Xiao, Curran, Dennis P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356113/
https://ncbi.nlm.nih.gov/pubmed/22515682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302260d
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