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A minimal fluorous tagging strategy enables the synthesis of the complete stereoisomer library of Sch725674 macrolactones
Four mixtures of four fluorous-tagged quasiisomers have been synthesized, demixed and detagged to make all 16 stereoisomers of the macrocyclic lactone natural product Sch725674. A new bare-minimum tagging pattern needs only two tags— one fluorous and one non-fluorous—to encode four isomers. The stru...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3356113/ https://ncbi.nlm.nih.gov/pubmed/22515682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302260d |
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