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Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations

KRAS mutations are highly prevalent in non-small cell lung cancer (NSCLC), and tumors harboring these mutations tend to be aggressive and resistant to chemotherapy. We used next-generation sequencing technology to identify pathways that are specifically altered in lung tumors harboring a KRAS mutati...

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Detalhes bibliográficos
Main Authors: Kalari, Krishna R., Rossell, David, Necela, Brian M., Asmann, Yan W., Nair, Asha, Baheti, Saurabh, Kachergus, Jennifer M., Younkin, Curtis S., Baker, Tiffany, Carr, Jennifer M., Tang, Xiaojia, Walsh, Michael P., Chai, High-Seng, Sun, Zhifu, Hart, Steven N., Leontovich, Alexey A., Hossain, Asif, Kocher, Jean-Pierre, Perez, Edith A., Reisman, David N., Fields, Alan P., Thompson, E. Aubrey
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356053/
https://ncbi.nlm.nih.gov/pubmed/22655260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00012
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