A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis

Aurora-A is a serine/threonine kinase that plays critical roles in centrosome maturation, spindle dynamics, and chromosome orientation and it is frequently over-expressed in human cancers. In this work, we show that Aurora-A interacts with the SUMO-conjugating enzyme UBC9 and co-localizes with SUMO1...

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Detalhes bibliográficos
Main Authors: Pérez de Castro, Ignacio, Aguirre-Portolés, Cristina, Martin, Benedicte, Fernández-Miranda, Gonzalo, Klotzbucher, Andrea, Kubbutat, Michael H. G., Megías, Diego, Arlot-Bonnemains, Yannick, Malumbres, Marcos
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355891/
https://ncbi.nlm.nih.gov/pubmed/22649767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2011.00050
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