The glycan-binding properties of the cation-independent mannose 6-phosphate receptor are evolutionary conserved in vertebrates

The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays an essential role in the biogenesis of lysosomes by delivering newly synthesized lysosomal enzymes from the trans Golgi network to the endosomal system. The CI-MPR is expressed in most eukaryotes, with Saccharomyces cerevisia...

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Bibliographic Details
Main Authors: Castonguay, Alicia C, Lasanajak, Yi, Song, Xuezheng, Olson, Linda J, Cummings, Richard D, Smith, David F, Dahms, Nancy M
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355666/
https://ncbi.nlm.nih.gov/pubmed/22369936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cws058
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