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Uptake Rate of Cationic Mitochondrial Inhibitor MKT-077 Determines Cellular Oxygen Consumption Change in Carcinoma Cells

OBJECTIVE: Since tumor radiation response is oxygen-dependent, radiosensitivity can be enhanced by increasing tumor oxygenation. Theoretically, inhibiting cellular oxygen consumption is the most efficient way to increase oxygen levels. The cationic, rhodacyanine dye-analog MKT-077 inhibits mitochond...

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Detalhes bibliográficos
Main Authors: Chunta, John L., Vistisen, Kerry S., Yazdi, Zeinab, Braun, Rod D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355126/
https://ncbi.nlm.nih.gov/pubmed/22616013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037471
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