Insufficient maintenance DNA methylation is associated with abnormal embryonic development

BACKGROUND: Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and de novo methylation directed by DNA methyltransferases (DNMTs), is important for embryo development. Abnormal function...

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Hlavní autoři: Yin, Li-Jun, Zhang, Yu, Lv, Ping-Ping, He, Wei-Hua, Wu, Yan-Ting, Liu, Ai-Xia, Ding, Guo-Lian, Dong, Min-Yue, Qu, Fan, Xu, Chen-Ming, Zhu, Xiao-Ming, Huang, He-Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355050/
https://ncbi.nlm.nih.gov/pubmed/22413869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-10-26
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